Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 6 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin B-6 [from 50 mg Coenzyme Pyridoxal-5-Phosphate (P-5-P) Monohydrate]
33 mg
1941%
Magnesium (from Magnesium Bisglycinate) (TRAACS®)
25 mg
6%
Top Medical Research Studies
9.5
We explored the effects of high serum homocysteine levels on blood clot risks within a group of 1,014 patients who experienced thrombotic events. This group underwent a thorough evaluation for various thrombophilic conditions. Notably, we found that 12% of these patients had treatable high homocysteine levels.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Read More
8
We explored the effectiveness of vitamin B6 in treating patients suffering from pulmonary thromboembolism linked to deficiencies in protein C (PC) and protein S (PS). In our analysis of two male patients, we found that they presented with common symptoms such as lower limb pain, chest pain, and even decreased vision.
Using color Doppler flow imaging, we identified lower deep venous thrombosis in both cases, while multislice CT angiography revealed pulmonary embolism. Interestingly, both patients had decreased levels of plasma PC and PS alongside elevated homocysteine levels. After recognizing their deficiencies, we introduced vitamin B6 along with anticoagulant therapy to manage their symptoms.
The incorporation of vitamin B6 appeared to significantly improve the patients’ conditions, indicating a potentially beneficial role in such cases. It highlights the importance of considering congenital thrombophilia and its treatment options for young patients experiencing recurrent blood clots without clear causes. Overall, vitamin B6 might enhance treatment outcomes in managing blood clots associated with these specific deficiencies.
Using color Doppler flow imaging, we identified lower deep venous thrombosis in both cases, while multislice CT angiography revealed pulmonary embolism. Interestingly, both patients had decreased levels of plasma PC and PS alongside elevated homocysteine levels. After recognizing their deficiencies, we introduced vitamin B6 along with anticoagulant therapy to manage their symptoms.
The incorporation of vitamin B6 appeared to significantly improve the patients’ conditions, indicating a potentially beneficial role in such cases. It highlights the importance of considering congenital thrombophilia and its treatment options for young patients experiencing recurrent blood clots without clear causes. Overall, vitamin B6 might enhance treatment outcomes in managing blood clots associated with these specific deficiencies.
Read More
9
We explored the intriguing case of a 30-year-old woman who experienced severe headaches and neurological symptoms, later linked to blood clotting issues. Initially diagnosed with suspected viral encephalopathy, she faced multiple health challenges including a pulmonary embolism and persistent migraines.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
Read More
Most Useful Reviews
9
Reliable and effective
1 people found this helpful
Excellent product! A neurologist recommended these capsules years ago. I order them every spring, as they significantly enhance blood vessel and nervous system function. The product's efficacy is clear, and I wholeheartedly recommend it for quality and affordability.
Read More
7.5
Improved condition confirmed
13 people found this helpful
The capsules I received were one size larger than those from Natural Factor. Children resisted them, and when I observed urticaria due to a high-protein diet, I ceased supplementation. However, a blood test showed a deficiency in B6, which can cause hives. Once I resumed giving it, his condition improved significantly.
Read More
9
Relieves stress effectively
2 people found this helpful
I'm very pleased with active vitamin B-6, which promotes amino acid metabolism and red blood cell formation. It's crucial for nerve health and alleviating stress. Regular supplementation has notably improved my sleep and emotional wellbeing, thanks to the fast absorption of these vegetarian capsules.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
- All Researches
9.5
We explored the effects of high serum homocysteine levels on blood clot risks within a group of 1,014 patients who experienced thrombotic events. This group underwent a thorough evaluation for various thrombophilic conditions. Notably, we found that 12% of these patients had treatable high homocysteine levels.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Read More
9
We explored the connection between vitamin levels and cerebral venous sinus thrombosis (CVST), particularly focusing on vitamin B6. Our case series documented three instances of CVST where patients presented with headaches, and two experienced additional symptoms like visual disturbances.
In our findings, we noted that two of these patients had notably low levels of vitamin B12, alongside the presence of hyperhomocysteinemia (hHcy). Treatment included low-molecular-weight heparin and supplements of vitamins B6, B9, and B12.
While vitamin B6 was used as part of the supplementation strategy, the specific impact of vitamin B6 alone on blood clotting wasn't thoroughly isolated in this study. All patients showed positive responses to the treatment, with follow-up imaging indicating resolution of the thrombosis in two cases.
This suggests that addressing vitamin deficiencies, particularly in those on vegetarian diets, is vital. Nevertheless, further dedicated research is necessary to determine the isolated effect of vitamin B6 on blood clots.
In our findings, we noted that two of these patients had notably low levels of vitamin B12, alongside the presence of hyperhomocysteinemia (hHcy). Treatment included low-molecular-weight heparin and supplements of vitamins B6, B9, and B12.
While vitamin B6 was used as part of the supplementation strategy, the specific impact of vitamin B6 alone on blood clotting wasn't thoroughly isolated in this study. All patients showed positive responses to the treatment, with follow-up imaging indicating resolution of the thrombosis in two cases.
This suggests that addressing vitamin deficiencies, particularly in those on vegetarian diets, is vital. Nevertheless, further dedicated research is necessary to determine the isolated effect of vitamin B6 on blood clots.
Read More
9
We explored the intriguing case of a 30-year-old woman who experienced severe headaches and neurological symptoms, later linked to blood clotting issues. Initially diagnosed with suspected viral encephalopathy, she faced multiple health challenges including a pulmonary embolism and persistent migraines.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
Read More
8
We looked into the effects of Vitamin B6, along with B12 and folic acid, on the risk of blood clots among Indian soldiers stationed at high altitudes. This study aimed to find out if these vitamins could lower homocysteine levels—an amino acid linked to an increased risk of thrombosis.
In a well-structured randomized field trial, 12,000 soldiers taking these vitamins were compared to another group receiving no intervention. After one year, we saw promising results: the soldiers who took the Vitamin B complex maintained healthier levels of homocysteine, plasminogen activator inhibitor (PAI 1), and fibrinogen, while their nitric oxide levels increased.
Most importantly, over two years, only five thrombotic episodes occurred in the intervention group compared to 17 in the control group. This indicates a clear protective effect of the vitamin regimen against thrombosis. Although the study did assess Vitamin B6 alongside B12 and folic acid, it points to its potential relevance in reducing blood clot risks in high-altitude conditions.
In a well-structured randomized field trial, 12,000 soldiers taking these vitamins were compared to another group receiving no intervention. After one year, we saw promising results: the soldiers who took the Vitamin B complex maintained healthier levels of homocysteine, plasminogen activator inhibitor (PAI 1), and fibrinogen, while their nitric oxide levels increased.
Most importantly, over two years, only five thrombotic episodes occurred in the intervention group compared to 17 in the control group. This indicates a clear protective effect of the vitamin regimen against thrombosis. Although the study did assess Vitamin B6 alongside B12 and folic acid, it points to its potential relevance in reducing blood clot risks in high-altitude conditions.
Read More
We explored a fascinating case involving a young woman who faced severe, recurring thrombotic events linked to exceptionally high levels of homocysteine in her blood—an amino acid known to be harmful to blood vessels. In her treatment, doctors combined anticoagulation therapy with warfarin and vitamin supplementation, including vitamin B6, vitamin B12, and folate.
While vitamin B6 is part of this treatment routine, the study doesn't clearly distinguish its individual effectiveness on preventing blood clots. After twelve years of treatment, the patient’s homocysteine levels did improve and stabilize within a moderate range, and notably, she did not experience any more thromboembolic incidents during this time.
This brings us to a crucial point: while vitamin B6 was included in her regimen, we cannot definitively say it made a significant difference on its own in managing blood clot risks. It appears to be one part of a larger picture that includes multiple treatments aimed at improving her condition.
While vitamin B6 is part of this treatment routine, the study doesn't clearly distinguish its individual effectiveness on preventing blood clots. After twelve years of treatment, the patient’s homocysteine levels did improve and stabilize within a moderate range, and notably, she did not experience any more thromboembolic incidents during this time.
This brings us to a crucial point: while vitamin B6 was included in her regimen, we cannot definitively say it made a significant difference on its own in managing blood clot risks. It appears to be one part of a larger picture that includes multiple treatments aimed at improving her condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reliable and effective
1 people found this helpful
Excellent product! A neurologist recommended these capsules years ago. I order them every spring, as they significantly enhance blood vessel and nervous system function. The product's efficacy is clear, and I wholeheartedly recommend it for quality and affordability.
Read More
7.5
Improved condition confirmed
13 people found this helpful
The capsules I received were one size larger than those from Natural Factor. Children resisted them, and when I observed urticaria due to a high-protein diet, I ceased supplementation. However, a blood test showed a deficiency in B6, which can cause hives. Once I resumed giving it, his condition improved significantly.
Read More
9
Relieves stress effectively
2 people found this helpful
I'm very pleased with active vitamin B-6, which promotes amino acid metabolism and red blood cell formation. It's crucial for nerve health and alleviating stress. Regular supplementation has notably improved my sleep and emotional wellbeing, thanks to the fast absorption of these vegetarian capsules.
Read More
8
Fights atherosclerosis effectively
2 people found this helpful
This vitamin is effective for reducing homocysteine in the blood, which indicates vessel inflammation. Reducing homocysteine levels aids in combating atherosclerosis, as cholesterol plaques adhere to inflamed areas. I've experienced positive results in managing my vascular health.
Read More
7.5
Reduces heart disease risk
1 people found this helpful
I highly recommend it for conditions like skin diseases and depression. P-5-P may also lower the risk of heart and vascular diseases. A neurologist introduced me to these capsules years ago, and I've been ordering them annually since—they genuinely help improve vascular health.
Read More
Frequently Asked Questions
7.5
Improved condition confirmed
13 people found this helpful
The capsules I received were one size larger than those from Natural Factor. Children resisted them, and when I observed urticaria due to a high-protein diet, I ceased supplementation. However, a blood test showed a deficiency in B6, which can cause hives. Once I resumed giving it, his condition improved significantly.
8
Fights atherosclerosis effectively
2 people found this helpful
This vitamin is effective for reducing homocysteine in the blood, which indicates vessel inflammation. Reducing homocysteine levels aids in combating atherosclerosis, as cholesterol plaques adhere to inflamed areas. I've experienced positive results in managing my vascular health.
9
Relieves stress effectively
2 people found this helpful
I'm very pleased with active vitamin B-6, which promotes amino acid metabolism and red blood cell formation. It's crucial for nerve health and alleviating stress. Regular supplementation has notably improved my sleep and emotional wellbeing, thanks to the fast absorption of these vegetarian capsules.
9
Reliable and effective
1 people found this helpful
Excellent product! A neurologist recommended these capsules years ago. I order them every spring, as they significantly enhance blood vessel and nervous system function. The product's efficacy is clear, and I wholeheartedly recommend it for quality and affordability.
7.5
Reduces heart disease risk
1 people found this helpful
I highly recommend it for conditions like skin diseases and depression. P-5-P may also lower the risk of heart and vascular diseases. A neurologist introduced me to these capsules years ago, and I've been ordering them annually since—they genuinely help improve vascular health.
8
We looked into the effects of Vitamin B6, along with B12 and folic acid, on the risk of blood clots among Indian soldiers stationed at high altitudes. This study aimed to find out if these vitamins could lower homocysteine levels—an amino acid linked to an increased risk of thrombosis.
In a well-structured randomized field trial, 12,000 soldiers taking these vitamins were compared to another group receiving no intervention. After one year, we saw promising results: the soldiers who took the Vitamin B complex maintained healthier levels of homocysteine, plasminogen activator inhibitor (PAI 1), and fibrinogen, while their nitric oxide levels increased.
Most importantly, over two years, only five thrombotic episodes occurred in the intervention group compared to 17 in the control group. This indicates a clear protective effect of the vitamin regimen against thrombosis. Although the study did assess Vitamin B6 alongside B12 and folic acid, it points to its potential relevance in reducing blood clot risks in high-altitude conditions.
In a well-structured randomized field trial, 12,000 soldiers taking these vitamins were compared to another group receiving no intervention. After one year, we saw promising results: the soldiers who took the Vitamin B complex maintained healthier levels of homocysteine, plasminogen activator inhibitor (PAI 1), and fibrinogen, while their nitric oxide levels increased.
Most importantly, over two years, only five thrombotic episodes occurred in the intervention group compared to 17 in the control group. This indicates a clear protective effect of the vitamin regimen against thrombosis. Although the study did assess Vitamin B6 alongside B12 and folic acid, it points to its potential relevance in reducing blood clot risks in high-altitude conditions.
9.5
We explored the effects of high serum homocysteine levels on blood clot risks within a group of 1,014 patients who experienced thrombotic events. This group underwent a thorough evaluation for various thrombophilic conditions. Notably, we found that 12% of these patients had treatable high homocysteine levels.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
We explored a fascinating case involving a young woman who faced severe, recurring thrombotic events linked to exceptionally high levels of homocysteine in her blood—an amino acid known to be harmful to blood vessels. In her treatment, doctors combined anticoagulation therapy with warfarin and vitamin supplementation, including vitamin B6, vitamin B12, and folate.
While vitamin B6 is part of this treatment routine, the study doesn't clearly distinguish its individual effectiveness on preventing blood clots. After twelve years of treatment, the patient’s homocysteine levels did improve and stabilize within a moderate range, and notably, she did not experience any more thromboembolic incidents during this time.
This brings us to a crucial point: while vitamin B6 was included in her regimen, we cannot definitively say it made a significant difference on its own in managing blood clot risks. It appears to be one part of a larger picture that includes multiple treatments aimed at improving her condition.
While vitamin B6 is part of this treatment routine, the study doesn't clearly distinguish its individual effectiveness on preventing blood clots. After twelve years of treatment, the patient’s homocysteine levels did improve and stabilize within a moderate range, and notably, she did not experience any more thromboembolic incidents during this time.
This brings us to a crucial point: while vitamin B6 was included in her regimen, we cannot definitively say it made a significant difference on its own in managing blood clot risks. It appears to be one part of a larger picture that includes multiple treatments aimed at improving her condition.
References
- Baby N, George M, Rajasekharan A, Ajith S, Zabeer M, et al. Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification. Ann Afr Med. 2024;23:496. 10.4103/aam.aam_138_23
- Woods E, Dawson C, Senthil L, Geberhiwot T. Cerebral venous thrombosis as the first presentation of classical homocystinuria in an adult patient. BMJ Case Rep. 2017;2017. 10.1136/bcr-2016-217477
- Kotwal J, Kotwal A, Bhalla S, Singh PK, Nair V. Effectiveness of homocysteine lowering vitamins in prevention of thrombotic tendency at high altitude area: A randomized field trial. Thromb Res. 2015;136:758. 10.1016/j.thromres.2015.08.001
- Glueck CJ, Smith D, Gandhi N, Hemachandra K, Shah P, et al. Treatable high homocysteine alone or in concert with five other thrombophilias in 1014 patients with thrombotic events. Blood Coagul Fibrinolysis. 2015;26:736. 10.1097/MBC.0000000000000276
- Awan Z, Aljenedil S, Rosenblatt DS, Cusson J, Gilfix BM, et al. Severe hyperhomocysteinemia due to cystathionine β-synthase deficiency, and Factor V Leiden mutation in a patient with recurrent venous thrombosis. Thromb J. 2014;12:30. 10.1186/s12959-014-0030-0
- Liu F, Zhu L, Chen P, Shi Z, Liu S. [Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013;38:971. 10.3969/j.issn.1672-7347.2013.09.018
- Mendiratta V, Prakash A, Jain A, Jain M. Isolated distal cutaneous thrombosis: an unusual presentation and an interesting etiology. Indian J Dermatol Venereol Leprol. 2011;77:494. 10.4103/0378-6323.82412
- Dworakowska D, Kazimierska E, Weyer-Hepka J, Dworakowski R, Jakóbiewicz-Banecka J, et al. [Hyperhomocysteinemia complicated by myocardial infarction and portal vein thrombosis--case report]. Pol Arch Med Wewn. 2006;115:234.
